Earthworm (Perionyx excavatus) Protein Hydrolysate: Hypoglycemic Activity and Its Stability for the Hydrolysate and Its Peptide Fractions

This study aims at exploring earthworm protein hydrolysate and its peptide fractions as a potential hypoglycemic agent by inhibiting α-amylase α-glucosidase. Firstly, the best hydrolysis conditions to gain hydrolysates with highest inhibitory activity (α-AIA) α-glucosidase (α-GIA) were figured out using one-factor test. Next, stability of their 5 recovered ultrafiltration membranes assessed employing tests in vitro digestion, thermal, pH treatment. The results showed that conditions, exhibited α-AIA 91.30 ± 2.51% α-GIA 44.69 0.47%. Specifically, <1 kDa fraction from expressed greater than acarbose, nearly same voglibose. enhanced after digestion treatment, whereas they remained over 40% treatment range 1 11 or heat 100 °C for 180 min. These data provide preliminary evidence develop functional food nutraceutical products activity.